Monday, 27 February 2012

biochemistry - What are the units of Q10 (temperature sensitivity)?

enter image description here



Figure. A schematic diagram showing the effect of the temperature on the stability of an enzyme catalysed reaction. The curves show the percentage activity remaining as the incubation period increases. From the top they represent equal increases in the incubation temperature (50 °C, 55 °C, 60 °C, 65 °C and 70 °C).



The Q10 is a unitless number, that summarizes the effect of raising temperature 10°C on the rate of a chemical reaction. A Q10 of 2.0 suggests that raising the temperature of a system by 10 °C will effectively double the rate of the reaction. This value would be expected for most chemical reactions occurring within normal physiological temperatures.



Mathematically, Q10 can be represented by the following expression:



Q10=left(frack2k1right)frac10t2t1



t2 = higher temperature
k2 = rate at t2
t1 = lower temperature
k1 = rate at t1



Usually the temperature difference is about 10 °C, then you can simplify the equation



Q10=left(frack1k2right)frac1010=frack1k2



Edit: You can easily calculate k form Arrhenius equation



k=AefracDeltaGRT



where k is the kinetic rate constant for the reaction, A is the Arrhenius constant, also known as the frequency factor, DeltaG is the standard free energy of activation (kJ/mol) which depends on entropic and enthalpic factors, R is the gas law constant and T is the absolute temperature.

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