There are always exceptions but you can consider some general rules.
A is 1 i.e the sequence that is perfectly complementary (2 is complementary but direction is parallel — cannot base-pair), then B would be 1 (siRNA). Reasons (some are just based on general rules of siRNA design):
- siRNAs have to be perfectly complementary
- The size is also perfect for a siRNA (21nt)
- U/A (2-3 residues) at the 5' of the siRNA
- U at 10th position
- GC content 43% (ideal 30-50%)
See here for guidelines for siRNA design.
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