Monday 22 January 2007

genetics - What is the advantage of circular DNA in bacteria?

To expand a little bit the other answer, I would also add that bacteria can have other (usually circular) DNA segments aside from their main chromosome. These are called plasmids and are double stranded molecules of DNA that can replicate autonomously.



Plasmids often carry genes that allow an organism to survive in certain conditions, for instance they could carry the resistance to an antibiotic, or the gene that encodes for a specific nutrient that may be absent in the environment and so on.



As the other answer says, plasmids can be transferred horizontally between bacteria in a process called bacterial coniugation, and that is made possible by the presence of a specific plasmid, called the F-plasmid in the donor. The F-plasmid encodes, amongst other things, for the F-pilus protein pilin, that allows the formation of the pilus necessary for DNA transfer.



Because of their properties, plasmids are widely used in laboratory as vectors, to transfer genetic material to cells in order to give them specific "abilities" (e.g. you could insert a gene that encodes for a certain receptor normally not expressed by the cells to allow its expression and test its function).



Finally, it is worth remembering that plasmids can also be find in eukariotes (e.g. in yeast).

No comments:

Post a Comment